The Dendritic Cell (DC) therapy by RGCC is a groundbreaking immune therapy designed to enhance the body’s ability to identify and destroy cancer cells while providing long-lasting immunity. By leveraging the natural function of dendritic cells, this therapy stimulates a powerful and targeted immune response against cancer. Here’s an overview of how it works and its applications:

How Dendritic Cell Therapy Works

1. Blood Sample Collection
   • A blood sample is taken from the patient to harvest dendritic cells and analyze cancer-specific antigens.
2. Cancer Antigen Identification
   • The therapy identifies specific antigens (markers) on the surface of the patient’s circulating cancer cells. These antigens are used to train the dendritic cells to recognize and target the cancer.
3. Activation of Dendritic Cells
   • The dendritic cells are activated and enhanced in the lab, becoming highly effective at presenting the cancer-specific antigens to other immune cells.
4. Stimulation of Immune Response
   • Once reinfused into the patient, the activated dendritic cells trigger a robust immune response, directing the body’s immune cells to seek out and destroy cancer cells.
5. Development of Memory Cells
   • The therapy also stimulates the creation of memory cells, providing long-term immunity to help prevent cancer recurrence.

Administration Schedule

• Delivered as three single-dose intravenous (IV) treatments spaced three weeks apart.

Therapeutic Goals

• Destroy existing cancer cells.
• Provide long-lasting immunity to prevent recurrence.

Applications of Dendritic Cell Therapy

1. For Solid Tumors
   • Effective against solid tumors in patients with stable cancer and good immune function.
2. Long-Term Immunity
   • Creates a durable immune memory, equipping the body to recognize and eliminate cancer cells if they return.
3. Good for Any Stage of Cancer
   • Suitable for all stages, provided the patient meets eligibility criteria and the cancer is stable.

Key Benefits of Dendritic Cell Therapy

1. Immune System Activation
   • Enhances the natural function of the immune system, enabling it to target and destroy cancer cells effectively.
2. Personalized and Targeted
   • Tailored to the patient’s cancer, focusing on specific antigens unique to their tumor.
3. Long-Lasting Protection
   • Stimulates memory cells for sustained immunity, reducing the risk of cancer recurrence.
4. Non-Toxic
   • Does not involve genotoxic drugs, chemotherapy, or radiation, making it a safer alternative for many patients.
5. Non-Genetic Therapy
   • Focuses solely on immune enhancement without altering genetic material.

Contraindications

Dendritic Cell therapy is not suitable for patients with:

• Active autoimmune diseases or infections.
• Recent or concurrent treatments such as chemotherapy, radiation, or radioactive seed therapy.
• High inflammation, cachexia, or other conditions compromising immune function.
• Pregnancy or children under 18 years old.

Not Suitable For:

• Hematologic cancers (blood).
• Compartmentalized or CNS cancers.

The Dendritic Cell therapy is a powerful, non-toxic option for treating solid tumors by harnessing the immune system’s natural ability to fight cancer. With its ability to provide long-term immunity and destroy existing cancer cells, it represents a significant advancement in immune-based cancer therapies for eligible patients.