RGCC BASIC PROTOCOL GUIDELINES – 9.1.22

As a practitioner, it is your responsibility to consider all of the factors that play a role in creating a personalized protocol for your patient. Factors to consider are:

• Current health status
• Health history
• Medical testing
• Imaging
• RGCC test results (CTC’s, stemness markers, gene expression, Conventional and non-conventional treatments)
• Mechanism of action of chemotherapy AND natural substances
• If the substances synergistic or competitive with chemotherapeutic agents AND other natural substances
• Timing of introduction of natural substances based on chemotherapeutic schedule (protocol when taking chemotherapy AND protocol when not on chemotherapy)

RGCC Tests/Baseline and Monitoring:

Baseline: Oncotrace or Oncotrail to determine starting point for CTC's and stemness markers.

Status Check Tests: Every 3 – 4 Months order an Oncotrace, Oncotrail or Oncocount to monitor CTC's and stemness markers to evaluate the effectiveness of the protocol.

Onconomics Plus: Every 9-12: Run a new Onconomics Plus panel. Cancer cells mutate over time. The substances that showed efficacy on the first test may have changed. It is important to update this information to ensure the protocols will have the greatest effect based on the state of the cancer cells at this new point in time.

Protocol Guidelines Based on RGCC Test Results:

1. Identify the natural substances which show efficacy against the cancer cells for the patient. These substances should have an efficacy rate above 5% with the ideal being over 15%.
2. From this group of natural substances, identify which are compatible and which are not compatible with the chemotherapeutic agent(s) the patient is receiving (if applicable).
   1. For those patients that are receiving chemotherapy:
      1. Select one agent from each class that shows the greatest efficacy rates AND when combined, have synergistic effects on each other.
      2. Be careful not to choose substances that have counteractive effect on each other or with the chemotherapy.
      3. These synergistic substances should be taken 5 days on, 2 days off.
      4. This 5 day on / 2 day off cycle should be repeated each week for 3 months.
      5. After 3 months, move to the next 2 effective, synergistic agents with the same 5 days on / 2 days off rotation.
   2. For those patients that are not currently receiving chemotherapy:
      1. Select one agent from each class that shows the greatest efficacy rates AND when combined, have synergistic effects on each other.
      2. Be careful not to choose substances that have counteractive effect on each other.
      3. These synergistic substances should be taken 5 days on, 2 days off.
      4. This 5 day on / 2 day off cycle should be repeated each week for 1-3 months.
      5. After 1-3 months, move to the next 2 effective, synergistic agents with the same 5 days on / 2 days off rotation.

Natural Substances only Rotation – Example Only

Select natural products from each class that show the greatest efficacy rates and have a synergistic effect with each other (do not choose ones that have any counteractive effects with each other). You can use choose one substance from each category. If there are no products shown to be effective in the class 2 category, you may choose two class 1 and one class 3 product instead.

The reason for rotation is that a certain number of csc will not be killed by apoptosis and will become resistant over time to the natural products as well as to the conventional treatments (Chemo, MOAB, and SMW drugs). The more contact time the faster the resistance occurs.

Month One:

Monday through Friday - Ascorbic Acid, Curcumin, C-Statin (oral)

Saturday and Sunday off all cytotoxic substances (Patient would continue their daily supplements and continue good life style habits, clean diet, relaxation, minimize stress, etc.)

Month Two:

Monday through Friday - Angiostop, Argaricus Blazel Muril, Artecin (oral)

Saturday and Sunday off all cytotoxic substances (Patient would continue their daily supplements and continue good life style habits, clean diet, relaxation, minimize stress, etc.)

Month Three: 

Apply the same instructions as outline above for months one and two.

Month Four:

If by this month there are still products to choose from then apply the same instructions as the previous
months. Not all patients will have enough substances for a four-month rotation.

Natural Substances with Chemotherapy Rotation – Example Only

Select one substance from each class that show the greatest efficacy rates and synergistic effect with each other but do not have any counteractive effects with each other or the chemotherapy. Counteractive substances compete, and will diminish or cancel the beneficial mechanism or effect.

You can use choose one substance from each category. If there are no products shown effective in the class 2 category, you may choose two class 1 and one class 3 product.

Months One to Three:

Monday through Friday - Ascorbic Acid and Curcumin – (Oral) (IV is available for both of these, however, due the concentrated nature of IV protocols, substances may only be given 2-3 times per week / with 1-2 days off / for maximum of 3 months)

Saturday and Sunday off all cytotoxic substances (Patient would continue their daily supplements and continue good life style habits: clean diet, relaxation, minimize stress, etc.)

Months Four to Six:

Monday through Friday - Quercetin and Argaricus Blazel Muril – (Oral)

Saturday and Sunday off all cytotoxic substances (Patient would continue their daily supplements and continue good life style habits, clean diet, relaxation, minimize stress, etc.)

NOTE: If the patient has a positive in class 2 over 15% you can substitute one of the class 1 products for the class 2 product.

Natural Substances that DO NOT work well together

• Genistein – Do not mix with Quercetin during the same month
• Vascustatin – Do not mix with Genistein during the same month
• Artecin – Do not use with Super Artemisinin during the same month
• Poly MVA – Do not mix with Lycopene on the same day
• IV – C – Do on opposite days of PolyMVA - or at least 6-8 hours after IV
• Salvestrol – Do not take with Resveratrol during the same month
• Artecin or Super Artemisinin - Do not do oral vitamin C on same day

At month three of the first year: You will want to run a new Oncotrace, Oncotrail or Oncocount to check the cell count as well as to see if the markers are changing. These are status checks. This is important to ensure that the protocol is indeed effective (as evidenced by the patients ctc number).

At the end of the initial 3 – 4 month rotation, if the cell count on their status check test decreased (this is what you should expect to see) you will have the patient repeat their initial rotation plan.

If the cell count increased on their status check test, then you need to evaluate what in the protocol or your patient’s compliance was not optimum and adjust accordingly.

After the first year of treatment, you can decrease the status check tests to every six months.

At the 9-12 month of the first year: You will want to order a new Onconomics Plus test. Based on these new results a new protocol will need to be prepared. On the follow up Onconomics Plus test results, you will see that often the natural substances that worked as a cytotoxin before may no longer work as well or at all. You may also see that natural products that did not work before are now showing as having a cytotoxic effect. Cancer changes and evolves, so this is to be expected.

You will also note these kinds of changes occur in the conventional therapies as well as the tumor genes also. Example: Cisplatin was 82% but is now 70%. PTEN was 50% but is now 25%.

Once again, based on your patient’s individual results there are supplements that have been found to be helpful in down or upregulating certain tumor gene markers. These products are not trying to induce apoptosis of the ctc and are in addition to the cytotoxic agent rotation.

Below are a few examples:

• Curcumin and ECGC can benefit P180
• Rosemary can benefit PTEN
• Melatonin can benefit TGF-b

It is also helpful to include in your protocol important specifics from their RGCC test.

Example: The need for hormone suppression (if the hormone markers were positive in their test). The need for proteolytic enzymes (If the MRP marker was high). Diet Restrictions (Based on the IGF-r1 and IGF-r2 results).