RCCC International North America Contact Information:

• Customer Relations:
  • Administrative questions
  • Help placing test and therapy orders
  • Help placing kit orders
  • Shipping questions
  • Portal and Order assistance
  • Payment issues or refund requests
  • Telephone: (800) 813-1372
  • Email Address: info@rgcc-international-com
• Clinical Support:
  • Technical and clinical related questions
  • Consultations: Tests € Therapies reviews
  • Telephone: (800) 813-1372
  • Email Address: support@rgcc-international-com
• Medical/Lab:
  • Order submission
  • Incoming samples confirmations
  • Therapy shipping confirmations
  • Email Address: medical@rgcc-com
  • NOTE: cc info@rgcc-international-northamerica.com for all correspondence with the lab.
• RCCC College:
  • Clinical and administrative education for practitioners and staff
  • Certification program
  • RCCC College questions and registration
  • Telephone: (970) 514-7039
  • Email Address: rgcc_college@rgcc-com

If you are not sure who to reach out to, email info@rgcc-international-northamerica.com or give us a call at (800) 813-1372. If we are unable to assist you, we will be able to forward you on to someone who will.

RCCC International Test Descriptions

RCCC Screening test:

Onco-D-clare:

• Onco-D-clare is a cancer screening test based on the interaction of molecular biology with machine learning This screening test can help detect cancer before symptoms appear.
• Peripheral blood mononuclear cells are isolated from blood samples, and gene expression analysis is performed in more than 90 Their expression profile is then used for the classification of the sample as cancerous or healthy.
• The Onco-D-clare test provides individuals with essential information to help them make better-informed decisions about future health and well-being.
• The test is clinically validated and highly accurate (≈93%).

RCCC Baseline and Ïollow-Up Tests:

Oncotrace:

• Used as a BASEĮINE and ÏOĮĮOW-UP tool to determine starting point, and monitoring effectiveness of treatment protocols
• May also be used for long-term monitoring following successful treatment for early detection of recurrence
• Detects presence of AĮĮ cancer types (except those of CNS origin)
• Detects the presences and number of CTCs in the blood (circulating tumor cells)
• Detects phenotype markers which are associated with tissue origin
• Detects Stemness Markers to monitor activity level of the CTCs to determine prognosis (potential for the cancer to proliferate (be aggressive), metastasize, resist treatment, or recur) and to determine when care is done
• Ïor hematologic (blood) € solid tumors
• Sample Type: Blood

Oncotrail RCCC:

• Use when you know the primary origin of the tumor for specific cancer types only (see list below)
• Used as a BASEĮINE and ÏOĮĮOW-UP tool to determine starting point, and monitoring effectiveness of treatment
• More suitable as a ÏOĮĮOW-UP tool following the Oncotrace once it is determined no secondary cancer is present
• Contains more biomarkers than Oncotrace for the specific type of cancer
  • Breast
  • Colon
  • CI
  • Įung
  • Melanoma
  • Prostate
  • Sarcoma
• May also be used for long-term monitoring following successful treatment for early detection of recurrence
• Detects the presences and number of CTCs in the blood (circulating tumor cells)
• Detects phenotype markers which are associated with specific tissue
• Detects Stemness Markers to monitor activity level of the CTCs to determine prognosis (potential for the cancer to proliferate (be aggressive), metastasize, resist treatment, or recur) and to determine when care is done
• Ïor hematologic (blood) € solid tumors
• Sample Type: Blood

Oncocount:

• Used as a ÏOĮĮOW-UP tool for monitoring effectiveness of treatment protocols
• Can be used as a BASEĮINE tool as well, when interested only in CTCs
• Detects presence of AĮĮ cancer types (except those of CNS origin)
• Detects the presence and number of CTCs in the blood (circulating tumor cells)
• Ïor hematologic (blood) € solid tumors
• Sample Type: Blood

RCCC Treatment Protocol Tests

Onconomics Plus:

• Most comprehensive individualized profile available (preferred for all baseline testing)
• Combination of Onconomics and Onconomics Extracts Panels
• Includes chemosensitivity testing of both chemotherapeutic agents AND natural substances
• Answers the question: “Which are the most effective chemotherapeutic agents and natural substances?”
• Detects the presence and number of CTCs (does not contain phenotype or stemness markers as does Oncotrace and Oncotrail RCCC)
• Analyzes validated tumor-related Cene expressions used for customization of treatment protocols
• Includes Resistance Ïactors to further refine timing and rotation of treatment protocols
• Includes Chemosensitivity (Pharmacodynamic) testing to determine the effectiveness of >50 Chemotherapeutic agents + 60 targeted drugs + >50 natural substances + 5 additional substances upon request at no additional cost
• Ïor hematologic (blood) € solid tumors
• Sample Type: Blood

Onconomics:

• Comprehensive, individualized profile
• Answers the question: “Which are the most effective chemotherapeutic agents?”
• Detects the presence and number of CTCs (does not contain phenotype or stemness markers as does Oncotrace and Oncotrail RCCC)
• Analyzes validated tumor-related Cene expressions used for customization of treatment protocols
• Includes Resistance Ïactors to further refine timing and rotation of treatment protocols
• Includes Chemosensitivity (Pharmacodynamic) testing to determine the effectiveness of >50 Chemotherapeutic agents + 60 targeted drugs + 5 additional substances upon request at no additional cost
• Ïor hematologic (blood) € solid tumors
• Sample Type: Blood

Onconomics Extracts+:

• Comprehensive, individualized profile
• Answers the question: “Which are the most effective natural substances?”
• Detects the presence and number of CTCs (does not contain phenotype or stemness markers as does Oncotrace and Oncotrail RCCC)
• Analyzes validated tumor-related Cene expressions used for customization of treatment protocols
• Includes Resistance Ïactors to further refine timing and rotation of treatment protocols
• Includes sensitivity (Pharmacodynamic) testing to determine the effectiveness of >50 natural substances + 5 additional substances upon request at no additional cost
• Anti-Cancer effect measured by studying:
  • Inhibition of - Signaling Transduction Pathways, Crowth Ïactor Receptors, and Angiogenesis Receptors
  • Immunostimulation/Immunomodulation - Release of Cytokines and increase of PBMC € NK cells
  • Cytotoxic Effect – Activation of Caspase and Cytochrome C
• Ïor hematologic (blood) € solid tumors
• Sample Type: Blood

Onconomics Extracts:

• Individualized profile showing the efficacy of treatment using natural substances
• Answers the question: “Which are the most effective natural substances?”
• Detects the presence and number of CTCs (does not contain phenotype or stemness markers as does Oncotrace and Oncotrail RCCC)
• Includes testing of >50 natural substances + 5 additional substances upon request at no additional cost
• Anti-Cancer effect measured by studying:
  • Inhibition of - Signaling Transduction Pathways, Crowth Ïactor Receptors, and Angiogenesis Receptors
  • Immunostimulation/Immunomodulation - Release of Cytokines and increase of PBMC € NK cells
  • Cytotoxic Effect – Activation of Caspase and Cytochrome C
• Ïor hematologic (blood) € solid tumors
• Sample Type: Blood

Immune Ïrame (for cellular therapies):

• When you need to evaluate the immune status of the patient to determine eligibility for use of Cellular It is also used for establishing a baseline and monitoring therapeutic response .
• Prerequisite for RCCC Cellular Therapies
• Important for treatment algorithm to determine eligibility for RCCC Cellular Therapies
• Determination of:
  • Cachexia (a.k.a. Wasting Syndrome) - A general state of ill health involving marked weight loss and muscle loss.
  • Presence and stimulation of DC’s (dendritic cells)
  • Specific Humoral and Cellular Immunity
  • Non-specific Cellular Immunity
  • Immunosuppressive Mechanisms
  • Activation of T and B Memory cells for long-term immunity

RCCC Advanced Diagnostic Tests

ArrayCCH RCCC:

• Use when you don’t know the primary origin of the tumor
• Detects chromosomal abnormalities that may be associated with the primary tumor
• Ïor hematologic (blood) € solid tumors
• Sample Type: Blood

ChemoSNiP:

• Pharmacokinetics (how body metabolizes drugs)
• Examines inherited variations in genes that dictate drug response and explores the way these variations can be used to predict whether a patient will have a good response to a drug, a bad response, or no response at
• When used together with data from chemosensitivity testing, it helps to narrow the selection to the most effective and least toxic therapeutic
• Sample Type: Blood or Swab

Metastat:

• Advanced test to detect blood born markers that can accurately determine whether a secondary tumor is likely to develop and its likely location
• Potential Sites of Metastasis:
  • Ceneral
  • Įung
  • Brain
  • Skin
  • Pleura
  • Įiver
  • Bones

CAMBISeq:

• Cancer Analysis Mutational Burden Instability Sequencing
• Technique: NCS (Next Ceneration Sequencing)
• Identifies beneficial mutations for cancer treatment (ÏDA approved treatments and in clinical trials only)
• The higher the number of mutations, the better the outcome for the patient when Immune Checkpoint Inhibitors (ICIs) are used
• Analyze mutational profile of CTCs
• DNA € RNA is studied to detect splice variants and fusions
• High Coverage = means the test is able to detect very rare mutations
• Typically used in medical oncology after first-line therapies have been exhausted to determine if there are any immunotherapy, targeted therapies, or clinical trials available as additional treatment options
• Predicts efficacy of immunotherapy or targeted therapy

RCCC International Therapy Descriptions

Ǫ-REstrain (cancer, virus, Lyme)

• RNA Interference Technology
• Works by blocking essential biological processes of the target (cancer cell, virus, Įyme, ) eliminating the next life cycle for that cell or organism (it cannot reproduce)
• It creates a 98% specificity to the target genes and it does not interfere with any other human (Effects target cells only)
• Administered as a single dose IV
• Remains active in the system for up to six months inhibiting the replication cycle of the target, or affecting the metabolism of the
• Coal: Eliminate existing cancer cells or microorganisms
• This is not an immune therapy
• Ïor hematologic (blood) € solid tumors
• Cood for all stages and small cancer burdens
• Not good for compartmentalized or CNS
• Contraindications:
  • Įarge cancer burden; tumors over 5 cm (single or total)
  • Tumors of the lung and liver – Ǫ-REstrain should be used with caution due to risk of TĮS (Tumor Įysis Syndrome)
  • Recent chemotherapy or radiation treatment
  • Radioactive seed therapy
  • Delta T Cell Therapy
  • Recent blood transfusions
  • Cachexia
  • Pregnancy
  • Children under 10 when used for the treatment of cancer
  • Children under 4 when used for the treatment of pathogens
• Sample Type: Blood

Dendritic Cell (DC) (cancer only)

• Immune Therapy – Activates or enhances the function of specific immune cells to find and destroy cancer cells
• Harnesses the action of Dendritic Cells by identifying specific antigens (markers) on the surface of the cancer cells circulating in the blood of an individual, allowing the immune system to seek out the cancer cells and destroy
• Also stimulates development of memory cells providing long lasting
• Administered as 3 single dose IV treatments, 3 weeks apart
• Coal: Destroy existing cancer cells and provide long-term immunity against the cancer
• This is not genetic
• Does not contain or involve the use of genotoxic (chemo)
• Ïor solid tumors
• Cood for any stage of cancer if the patient still has good immune function and the cancer is stable.
• Not good for compartmentalized, hematological, or CNS
• Contraindications:
  • Active auto-immune disease
  • Recent blood transfusion
  • Active infections
  • High inflammation
  • Cachexia
  • Pregnancy
  • Immunosuppression therapy
  • Recent or concurrent chemotherapy or radiation
  • Radioactive seed therapy
  • Camma Delta T Cell Therapy
  • Children under the age of 18
• Sample Type: Blood

Vaccine Prep (ATA) (cancer only)

• Immune Therapy – Activates or enhances the function of specific immune cells to find and destroy cancer cells
• Utilizes cellular fragments of dying CTCs such as cellular membrane, intracellular organelles, mitochondria, and cellular RNA and DNA, to stimulate development of Dendritic Cells.
• Administered as 6 single dose IV or subcutaneous injections, 7 days apart over 9 weeks (includes 3 week rest period)
• This is not a genetic therapy
• Does not contain or involve the use of genotoxic (chemo) drugs
• Coal: Destroy existing cancer cells and provide long-term immunity against the cancer
• Ïor Solid tumors
• Cancers that do NOT respond to this therapy:
  • Hematologic (blood) Cancers
  • CNS Cancers
  • Testicular Cancer
  • Compartmentalized Cancers
• Cood for early-stage cancers and patients that have not undergone conventional chemo or radiation
• Contraindications:
  • Active auto-immune disease
  • Recent blood transfusion
  • Active infections
  • High inflammation
  • Cachexia
  • Pregnancy
  • Immunosuppression therapy
• Recent or concurrent chemotherapy or radiation
• Radioactive seed therapy
• Camma Delta T Cell Therapy
• Children under the age of 18
• Sample Type: Blood

Clavic-Ǫ-RE (cancer only)

• Immune Therapy – Activates or enhances the function of specific immune cells to find and destroy cancer cells
• This is an Autologous Adoptive Cellular Therapy
• Harnesses the power of both innate and adaptive immunity
• Utilized a combination of immune cells including macrophages and Natural Killer cells (innate immune cells) and activated Dendritic Cells, T cells and antibody producing plasma cells (adaptive immune cells), to create a multi-dimensional immune response.
• Administered as 3 single dose IV treatments, 2 weeks apart
• Coal: Destroy existing cancer cells and provide long-term immunity against the cancer
• This is not genetic
• Does not contain or involve the use of genotoxic (chemo)
• Ïor hematologic (blood) € solid tumors
• Cood for cancer over stage 2B
• Not good for compartmentalized or CNS cancers
• Contraindications:
  • Active auto-immune disease
  • Recent blood transfusion
  • Active infections
  • High inflammation
  • Cachexia
  • Pregnancy
  • Immunosuppression therapy
  • Recent or concurrent chemotherapy or radiation
  • Radioactive seed therapy
  • Camma Delta T Cell Therapy
  • Children under the age of 18
• Sample Type: Blood

How To Use the RCCC Doctor’s Portal:

Open your webpage browser and go to the following web address: Portal - RCCC Croup (rgcc-group.com)

1. Click “Sign In” in the upper righthand corner of the webpage.
2. Sign into the Portal using your credentials.
   • If this is your first-time logging in, you will need to locate an email from the RCCC College team, titled “RCCC Practitioner Portal Credentials”. This email contains your login information and temporary password.
   • Once logged in for the first time, you will be prompted to change your password.
   • Ïor all future password changes, or in the event you forget your password, please click “Difficulty Signing In?” below the login screen and an email will be sent to you to reset your This email is only valid for 15 minutes.
3. Once logged in, you will see a bar along the top of the screen, which will allow you to complete many different The screen will look like this:
   
4. Take a moment to explore each tab to become familiar with how to navigate around the portal and find the resources you

Updating Your Profile Information:

The first time you log into the Doctor Portal, you will want to make sure to update all of your Profile Information. In the upper righthand corner, you will see a tab that says “YOUR NAME Profile”. Please click here and follow the instructions below to update your profile information:

1. Each box with an asterisk next to it is Please be sure to update each box.
   • Note: The system will not accept the form if there are any spaces before or after the 2-letter state Please check to make sure that there are no spaces prior to submitting.
     
2. If there is a secondary email you would like on file, please enter it into the “Email 2” field.
   • Please note: You cannot change your primary email address on file once your Portal is You can only update your secondary email address.
   • If at some point, you would like to update the primary email address, please notify the Customer Relations team at info@rgcc-international-northamerica.com for assistance.
3. If you would like the system to send you a copy of patient results once you have opened them, please check the box below the profile information to “Opt In”.
4. CDPR Compliance refers to a privacy protection act in You must select Yes.
   
5. Once you have updated all of your profile information, click “Save”. This will save your information and bring you back to the home page of the

Placing Kits-Vials Requests:

Kit ordering should be done prior to scheduling any patients for testing or therapies. Supply orders can take up to 7 days to arrive. Actual shipping times will vary depending on geography and the day of the week you place your order. Please keep track of your inventory and place your order with enough time to ensure supplies are available when you need them. Expedited or Rush shipping is NOT available.

Please follow the below steps to place your order(s) for Kits and Supplies through the Portal.

1. Ïirst, you will need to click on “Kits/Vials Request”
   
2. Next, you will click on “New Request” in the upper righthand corner of the page.
   
3. At the top of the Kits/Vials Request page, you will find instructional videos which review the ordering process and how to pack the kit for Please use the videos as needed to guide you through these processes.
4. The system is designed to be customizable and can be adjusted to meet the needs of your When creating the order, you will input the exact number of Vials, Blood Draw Sets, Isoboxes, and Prepaid Shipping Įabels you need.
   • Please take note of the subtext below each field, outlining the contents of each item.
   • Note: You will only need to select either a USA ÏedEx Įabel OR a Canada ÏedEx Įabel, depending on the location of your office or patient (for drop-shipping).
   • Please note that if you are a USA provider and you have a patient in Canada you will not be able to order a Canada ÏedEx label to drop ship to your You will still place the drop ship supply order through the Portal. However, you will need to email info@rgcc-international-northamerica.com to request a shipping label for the return shipping. This will also apply if you are a Canadian provider who needs to drop ship a supply order to a USA patient.
     
5. Supply orders automatically ship to the address you entered in the Doctor’s Profile section.
6. If you would like to drop-ship a kit to a patient or have supplies delivered to a different location than the address you entered in the Doctor’s Profile section, you can edit the delivery address by clicking on the purple “Delivery Address” bar at the bottom of the Please note that all fields in this section are mandatory. Once you have entered all necessary information, click “Save”.
   
7. Please verify all of the details of your order then click “Submit.”
   • If you changed the delivery address, please ensure it is If you did not change the address, the shipment will automatically ship to the registered address in your Portal.
     
8. Once the order has been submitted, it will show as “Pending” on the Kits/Vials Request As soon as it has shipped, the status will update to “Shipped” and the Tracking Number will appear next to the shipment.
   • If you need to review the details of your order, click “Details”. This will show you which supplies you ordered.
     
9. Order Size:
   • Supplies are readily available and easy to Please order the amount of supplies you need with a small buffer so you will have enough supplies on hand for scheduled RCCC blood draws plus a few extra for unexpected or unscheduled blood draws.
   • Order supplies no more than 1 month at a Please DO NOT stock up for several months.
   • If you place a large supply order well beyond your test/therapy order history, your order will not be approved, and you will be asked to modify the order before it is shipped.

Adding New Patient Information to the Portal:

A Patient must be added to the Portal prior to placing an order. If the patient already exists in your Portal, please disregard this section and jump to “Placing an Order in the Portal” below.

1. First you will need to click on “My Patients” then “New Patient”
   
2. Enter in the mandatory fields: “Patient Name”, “Date of Birth”, and “Cender”
3. You will also need to comply with CDPR for each new patient. 
   
4. If you continue to scroll down, you will see an area to add the patient’s Medical Record and Personal The personal information section is not as important as the medical record. Please complete the medical records section as much as possible. This information is VERY helpful to the lab team when processing your patient’s order(s).
5. At the bottom of the page, you will see the option to “Consent to ” Please note that this is not mandatory, however, RCCC is a research lab so it is highly encouraged to assist in furthering our mission.
   • Please note, if the patient wishes to place Add-On orders using blood samples already at the lab, the patient MUST consent, or their blood sample will be discarded at the completion of testing and will not be stored at the lab for use in future orders.
     
6. Once you have completed the patient profile click “Save”. The Portal will bring you back to the “My Patients” tab where you can place your order(s).

Placing an Order in the Portal:

All orders need to be placed in the Doctor’s Portal. (There are a few exceptions, including Physician Personal Testing Orders, Ïollow Up Orders, etc. that will be discussed later in this section.)

1. To place a new order in the Portal, go to the “My Patients” tab and locate the patient you would like to place the order Then click on “Orders”.
   
2. Next, click on “New Order Ïor ” in the upper right-hand corner.
   
3. Enter in the vial number(s) for the order.
   • If this is an add on order (for Ǫ-REstrain, where the lab already has blood at the lab), enter in “0” for the vial
   • If there is more than one vial of blood being submitted to the lab, enter all vial numbers by clicking “Add Extra ”
   • It is important for you to know exactly how much blood is required for each test or therapy you wish to order, to reduce waste but also to ensure that your patient does not need to have more blood draws than necessary. Please reach out to the Customer Relations team for assistance (info@rgcc-international-northamerica.com), if needed.
4. Once the Vial Number(s) have been entered click “Next Step”.
   
5. This section is where you will select the tests and/or therapies for the order.
   • Please note: BioCentaur is an RCCC sister lab. Ïor your convenience, the order form allows you to place orders for BioCentaur tests as Since RCCC and BioCentaur are separate labs, when ordering both RCCC and BioCentaur tests and/or therapies for the same patient, the orders must be placed separately.
6. Select the tests and/or therapies you would like to As you make your selection, you will see them appear in the shopping cart at the bottom of the page.
   • Please note: The prices for all RCCC tests and therapies are set in Euros.
     The price of the test/therapy will vary slightly day to day based on the current exchange rate. The $US price shown in the order form next to the item, reflects the price based on the exchange rate on that day.
   • Additional Substances:
     • If you are submitting an order for the Onconomics Extracts or Onconomics Plus test, you have the option to add on up to five additional substances at no additional Each substance beyond the fifth one is charged at 50 Euros.
   • Adding Substances Not Readily Available at the Įab:
     • You may submit additional substances to be tested if they are not already available at the Please refer to the “How to Send Additional Substances” guide.
     • Additional substances must be submitted with the blood sample for testing.
     • You MUST include all relevant substance information with the sample; brand name, substance name and quantity, expiration date, dosage, etc.
   • When adding substances, you must enter the Active Ingredient, Brand Name, and Class of Drug.
     
   • Natural Substances/Extracts can be added in the
     • Onconomics Plus
     • Onconomics Extracts
     • Onconomics Extracts+
   • Drugs/Chemical Substances which are used for Complementary-Alternative Medicine (CAM), such as DMSO or Methylene Blue, can be added in the
     • Onconomics Plus
     • Onconomics Extracts
     • Onconomics Extracts+
   • Drugs which are used for cancer only, eg MoAb, SMW etc (Įazertinib-Amivantamab) can be added in
     • Onconomics Plus
7. Once you have selected all tests and therapies, click “Next Step”.
   
   *It’s important to note that Ǫ-REstrain therapies are separated out by Cancer Ǫ-REstrain and Non-Cancer Ǫ-REstrain (virus and other pathogens)
   
8. The following page is where you will enter in Diagnosis information for your patient.
   
9. Ïor Cancer Related Tests, you will need to enter in the Primary Cancer Type and Present Stage.
   • Please Note: if you are conducting a healthy screening, you will need to select “Healthy/Screening” for the Cancer This will auto-populate “Not Applicable” into the Present Stage section of the form.
     • If it’s a healthy screening but the patient has a strong family history or predisposition to develop cancer, please notate this in the patient’s profile or put a note on the order so the lab is aware.
   • If the patient is currently in Remission, please enter their cancer type and select “Remission” from the Cancer Stage dropdown
   • If the patient is healthy but received an indication of “Cancer” on the Onco-D-clare test, please still put “Healthy/Screening” as their diagnosis. The Onco-D-clare test is a pre-screening and not a diagnostic tool.
   • IMPORTANT: IT is VERY important that the diagnostics for the patient is input The Cancer type, stage, and other diagnostics determine the scientific process at the lab. Different diagnoses may require utilizing different growth mediums. Therefore, incorrect diagnosis information may affect accuracy of results. If you have any hesitations regarding the patient’s current diagnosis or stage, please inform the lab immediately so they can adjust accordingly.
     
10. Enter in the “Date of Primary Diagnosis”
    
11. For Non-Cancer Related Tests, you will type in the diagnosis.
    
12. Then click “Next Step”
13. Next, select “In Office ” This indicates the payment will be made at the time the order is being created with the patient’s or your office’s credit card. The option to send an invoice to a remote patient to pay RCCC directly is in development. However, currently that option is not available.
    
    • Please note: Although the patient may use their credit card for the payment, financial responsibility of the order falls onto the RCCC Network All orders, add-ons, etc. must be paid in full. If the payment is not made, the ordering doctor may be locked out of their Portal until payment for all orders is resolved and the account is brought back into good standing.
14. If you placed an order for a Therapy, you will need to enter in the Therapy Delivery Details, as shown below. Please include the address of the office you would like the therapy shipped Please confirm this information with the lab, upon receipt of the Incoming Samples email, if the delivery address is different from your Portal address.
    
15. AWB Tracking Number: This field is not required at this However, if you have the tracking number, please enter it into the system here for records keeping purposes.
    
16. Click “Next Step”.
17. The Cancellation Policy is listed in the next Please be sure to review this with your patient.
    
18. You will also see the Terms and Conditions listed Please review them with your patient and have them sign the “Patient Signature” field.
    • Please Note: You may choose to “Click Here” (option 2) to accept an automatically created signature for your patient.
      
19. Once the signature is complete, click “Checkout”. This is where you can review the order and submit payment for it to be processed.
20. Once you have verified the order is correct,
    • Enter the credit/debit card information
    • Verify the email address you would like the payment receipt to be sent It will auto populate with the primary email address in the doctor’s profile section. If you want the receipt to be sent to a different email address, you can type it in here.
    • Note: We recommend sending the receipt to an office email address even if the patient uses their credit card to make the Once received, print/download a copy for your records, then forward the receipt email to the patient.
    • When you are confident all information is correct, click “Pay $ ”
      

21. Once the order has been paid, the “Download Documents” button will You can now download and print the Order Confirmation form necessary to send along with the blood sample. The “Ïull Pdf” is for your records - we do not need a copy of this document.

22. IMPORTANT: Placing an order is a 2-step

• Step 1: Place the order in the portal as shown above.
• Step 2: Send the Order Confirmation form to the lab.
• The order will not be processed until the Order Confirmation form is received by the lab in the box when sending a blood sample or via email when placing an Add-On Ǫ-REstrain order.

23.Please Note: On occasion, the Order Confirmation form will need to be submitted or resubmitted after the blood sample has been shipped to the Ïor these instances, simply come back to the original order, download the document, and email to medical@rgcc-genlab.com and cc info@rgcc-international-northamerica.com for processing.

24. Also Note: If you have placed multiple orders for the same patient (ie; a BioCentaur Order AND an RCCC Order) you will need to include AĮĮ Order Confirmation Documents with the blood sample.

RCCC Cellular Therapies Order Information

• Cellular Therapy Emails
  • Therapy Shipping Confirmation Email
    • Because cellular therapies are time sensitive and must be administered within 7 days of shipping from the lab, you will receive a confirmation email a week prior to the shipping date, letting you know the therapy is complete and ready to ship and asking that you confirm that the lab may send it.
    • If you do not respond to the email to confirm that the lab may send it out, the therapy will not ship and will be placed in the queue for shipping with the next therapy shipment.
    • The therapy will not ship until the lab receives confirmation from you.
  • Therapy Shipping Notification Email
    • When the therapy is shipped on Thursday, you will receive an email with the tracking number (AWB Number) so you can follow the shipment and know when it will arrive in your office.
    • For US based offices, the therapy will be delivered by the end of business Tuesday.
    • For Canadian offices, the therapy will be delivered by the end of business Wednesday.
    • If the therapy is not delivered within the 8-day administration window, please notify the branch office and lab and a replacement therapy may be sent (Cellular therapies only).
• Should we order and send blood for the prerequisite tests and the therapy at the same time?
  • To produce the best quality therapies, the lab requires fresh blood and will begin producing the therapy as soon as the sample arrives.
  • If you are certain which therapy to order, you can order both the pre-requisites and the therapy at the same time.
  • If you DO NOT know which therapy to order and need the prerequisite test results to make that determination, then you will place the therapy order after the results have come back and you will send a fresh sample to the lab.
• If shipping therapy to a different office for administration (collaborating office):
  • It is not uncommon for two RCCC offices to collaborate with a single patient when the patient lives at a distance from the primary In these instances, the primary office coordinates with an RCCC registered office geographically closer to the patient for therapy administration.
  • When collaborating, the primary office should submit AĮĮ orders for the patient to avoid mistakes and confusion.
  • You can notify the lab when responding to the Incoming Samples email that you wish to have the therapy shipped to a different The lab will update the shipping address and send the therapy to the collaborating office. Always CC the branch office into these communications.
  • The collaborating office MUST be an RCCC registered office who is adequately trained on therapies and therapy A release of records might be necessary - this is up to the office to determine and execute.

BioCentaur Orders:

BioCentaur is a sister lab that offers testing for viruses, Įyme, and coinfections. These tests have been included in the Portal for your convenience.

• Since it is a separate lab, when placing orders that include both RCCC and BioCentaur options, these orders must be placed Once you select an item from the RCCC menu, the BioCentaur tab will lock, and vice versa.
• To place an order for items in both labs, complete your order for RCCC, then place a second order for BioCentaur.
• Make sure to download, print, and place BOTH Order Confirmation forms in the box with the blood sample when shipping to the
• BioCentaur also offers 2 types of discount orders:
  • When you order PrimeSPOT and PaldiSPOT in the same order (20% discount)
  • When you place a repeat PrimeSPOT within 6 months of the 1^st order (150 CBP)
    • Please Note: The discounted price is only available for the 2nd The discount cannot be applied to any subsequent orders, regardless of when they are placed.
• This iteration of the portal is not set up for discounted These will be placed as Įetterhead Orders. The Įetterhead Order will be sent to the lab in place of the Order Confirmation Document.

Upgrade Orders:

Occasionally, you may need to upgrade an order after the blood sample has been sent to the lab.

• If you wish to upgrade an existing order (ex. Oncocount to Oncotrace or Onconomics to Onconomics Plus), this can only be done if processing has not been completed and the results have not been reported out.
• Since the original order is locked once payment is made, you must email Customer Relations at info@rgcc-international-northamerica.com and the lab at medical@rgcc-genlab.com to inform them of the change and a manual invoice will be generated for the difference in DO NOT cancel the order.

Add-On Orders:

Occasionally, you may need to submit an Add-On Order where a blood sample is already at the lab. Please see the details below:

• Adding additional tests after the original order has been submitted (ex. Original order is an Oncotrace, and you want to add on an Onconomics Plus)
  • This can only be done if the order is still being processed and results have NOT been reported out.
  • Since the original order is locked once payment is made, a new order must be completed, and the new Order Confirmation form must be emailed to the lab at medical@rgcc-genlab.com. Please make sure to CC the branch office email address into all correspondence with the lab.
• Adding additional substances to an Onconomics, Onconomics Extracts, or Onconomics Plus panel after the order has been submitted.
  • This can only be done if the order is still being processed and results have NOT been reported out.
  • Since the original order is locked once payment is made, you must email Customer Relations at info@rgcc-international-northamerica.com and the lab at medical@rgcc-genlab.com to inform them of the change and a manual invoice will be generated for the difference in DO NOT cancel the order and place a new one.
• Ǫ-REstrain orders which meet the below requirements:
  • Ǫ-REstrain for Įyme and Coinfections:
    • Patient must have lab results showing positive infection within 6 months of the draw date.
    • The patient’s blood must have been received at the lab within the last 6 months.
    • A maximum of four Ǫ-REstrain for the same target are allowed in a 12-month period, spaced at a minimum of 3-months The lab requires updated test results that show the pathogen is still present before a repeat for the same pathogen will be allowed.
    • Also note: The lab requires roughly 10ml of blood for each Ǫ-REstrain. Thus, even if you meet the above requirements for an add-on Ǫ-REstrain order, the lab may still require additional blood quantity to make the Ǫ-REstrain. If there is any question as to whether the lab has enough blood, please email them directly to confirm (medical@rgcc-genlab.com) and CC the info@ email address into the correspondence.
• Ǫ-REstrain for Cancer:
  • Patient must have CTC count done (with RCCC) within the past 6 months.
  • IMPORTANT NOTE: If the patient has undergone any therapy since their last blood draw, the lab MUST receive new blood for the  Ǫ-REstrain to be most effective. This is in the best interest of your patient.
  • Also note: The lab requires roughly 10ml of blood for each Ǫ-REstrain. Thus, even if you meet the above requirements for an add-on Ǫ-REstrain order, the lab may still require additional blood quantity to make the Ǫ-REstrain. If there is any question as to whether the lab has enough blood, please email them directly to confirm (medical@rgcc-genlab.com)

Add-On Onco-D-clare Orders

When a patient receives a result of “Positive Reaction of PBMC to Cancer Cells” on an Onco-D-clare test, they have the option to order an Oncotrace, Oncotrail RCCC, or Oncocount within 48 hours of the results posting, without being required to submit new blood to the lab. This order is placed as an add-on order, and the Order Confirmation

Document must be submitted to the lab for processing. Please follow the instructions below:

1. If you receive a result of “Positive Reaction of PBMC to Cancer Cells” on an Onco-D-clare screening test, and the patient would like to order an Oncotrace, Oncotrail RCCC, or Oncocount, you have 48 hours from the time the results post to do so.
2. Ïirst, you will login to the RCCC Portal, and place the order for Oncotrace, Oncotrail RCCC, or
   1. Note: You cannot order an Onconomics panel or other testing - you can only order an Oncotrace, Oncotrail, or If you’d like to order an Onconomics panel or other testing, you will need to send a new blood sample to the lab for processing.
3. Next, you will download the Order Confirmation Document and email it to the lab (medical@rgcc-genlab.com), CC’ing the branch office into the email (info@rgcc-international-northamerica.com).
   1. Note: You only have 48 hours from the time the results post to send this document to the Any orders received after 48 hours will require new blood.
4. Please make sure to follow up with the lab if no confirmation or order has been received within 24 You can do this by emailing the lab and the branch office again to inquire on the status of the test order.
5. Results for the Oncotrace, Oncotrail RCCC, or Oncocount should post to the Portal within 5-7 days.

How to Place an Add-On Order:

Ïor all Add-On Orders, you will follow the same steps outlined above under “Placing an Order in the Portal” AND follow the steps below to ensure the order is received and processed by the lab.

1. Once you have placed the order and downloaded the Order Confirmation Document from Step 5 in the Portal, you will need to email it to the lab for processing (medical@rgcc-genlab.com).
   • As mentioned above, you will want to enter in “0” for Vial This will indicate to the lab that you would like to use blood previously submitted.
2. Emailing the document to the lab for processing:
   • Address the email to the medical team (medical@rgcc-genlab.com) and CC the Customer Relations Team into the email (info@rgcc-international-northamerica.com)
   • Title the email “Add-On Ǫ-REstrain for PatientName”
   • Attach the Order Confirmation Document to the email.
   • In the body of the email, please include a brief explanation of who and what the order is for.
     • ie; “Please see the attached Order Confirmation Document for patient Jane Doe. This order is for an Ǫ-REstrain for and . Please confirm receipt of this order and advise if you need anything further.”
   • Once the email has been sent, please await confirmation that the lab has received the If you have not received confirmation within 3 business days, please send them a “Kind Reminder” email.
   • IMPORTANT: The lab CANNOT process an Add-On order without the Order Confirmation It is imperative that this document is emailed to the lab at the time of order, to not delay patient care.

Letterhead Orders

The current iteration of the portal is not set up to handle certain types of orders. In these cases, you will submit the order on your office letterhead and either include it with the blood sample or email it to the lab for processing (medical@rgcc-genlab.com).

• Types of Letterhead Orders:
  • Cellular Therapy Ïollow-Up Testing ($0 Transaction)
    • These tests are included in the price of the package, therefore there is no charge when submitting these tests.
  • Practitioner’s Personal Orders ($0 Transaction)
    • RCCC offers complimentary testing and therapies for active practitioners and their immediate family members, including mother, father, spouse, and children, after 6 paid orders have been Please be aware that this offer is specifically for these immediate family members and does not cover in-laws or other members of the provider’s extended family.
  • BioCentaur Discounted Orders
    • These orders will be invoiced manually by Please email them directly at Susan.Bater@biocentaur.com with any questions you may have.
• How To Place a Letterhead Order:

1. When placing an order that meets the criteria outlined above, you will need to include the following information on company letterhead:
   • Date of Order
   • Name and Date of Birth of Patient
   • Name of Network Doctor
   • Tests and/or Therapies Ordered
   • Vial Number
     • If using blood at the lab, please indicate this instead of the vial number
   • Brief explanation of the reason for a letterhead order
     • ex; “This order is for an Oncotrace and Immune Ïrame for Jane Doe, mother of Doe” or “This is the 120 day follow-up test for Clavic-Ǫ-RE, included in the therapy package price”.
   • Signature of Network Doctor
2. You will either submit the order with the blood sample or email it to the lab (medical@rgcc-genlab.com) and cc the Customer Relations team into the email (info@rgcc-international-northamerica.com)
   • Always make sure you receive confirmation from the lab on AĮĮ If you have not heard confirmation from the lab within 2 business days, send them a “Kind Reminder” email.
   • Please note: You cannot be certain that an order has been received by the lab until it has been confirmed either with an Incoming Samples email or confirmation

Important Email Correspondence from the Lab:

• Incoming Samples Email:
  • When the lab receives a blood sample, they will send your office an email with the order information and indicate if there is any additional information needed to process the They will also advise if the sample did not pass Ǫuality Control and provide the reason why. This email is titled “Incoming Samples” followed by the date the blood sample was received at the lab.
    • The “Incoming Samples” email serves as confirmation of the blood arriving at the lab, as well as an opportunity for the Network Doctor to review the order details and make any necessary changes.
    • Any missing information will be in red font in the appropriate Always make sure to check the “Office Comments” section of the email.
  • Missing Order Confirmation Document:
    • In the event an Order Confirmation Document is not received with the blood sample, the lab will request that the document be sent to them via email for The Order Confirmation Document is required for locating the order in the system. Without it, the order cannot be processed.
    • The Incoming Samples email will include a message resembling the one below if the Order Confirmation Document is missing from the order.

• Missing or Confirming Patient Information:
  • Occasionally, patient information in our systems may not match the information in the order. In this case, the lab will request for the Network Doctor to confirm the information received (date of birth, diagnosis, etc.)

• Missing Lab Results:
  • Positive lab results are required for all Micro Q-REstrain orders. If lab results are not submitted with the blood sample, or the labs we have on file are outside of the 6-month window, the lab will request new ones to be sent.

• Therapies List Notification Email:
  • Prior to cellular therapies being shipped, the lab will send out a Therapies Įist email the week before, requesting the Network Doctor to confirm that they are ready for the therapies to be They will also request for confirmation of AĮĮ details, including the delivery address.
    • Prior to confirming the therapy, ensure that the patient is ready for the therapy to be If not, you will need to notify the lab to postpone the therapy. The therapy will be postponed until the next shipment, unless otherwise indicated by your office.
    • You MUST reply to customer relations and the lab and advise them on whether to ship the therapy on the date indicated in the If confirmation is not received by Ïriday at 5pm (MST), the therapy will not be shipped until the following scheduled shipment.
    • Please note that the schedule for Therapies emails and shipping may be different for Canadian doctors, but the principal is still the Therapies must be confirmed or they will not be shipped.
    • Please also note that this is only for Cellular Therapies and not for shipments only containing Ǫ-REstrain.
    • The Therapies Įist email will resemble the screenshot below:

• Therapies Shipment Notification:
  • On the date the therapy is shipped, a notification will be sent to the Network Doctor informing them of the shipment.
  • The email will include patient name(s), therapy vial ID(s), and the therapy name(s).
    • IMPORTANT: AĮĮ therapies are shipped without patient information on the It is imperative that you keep this email for reference. Once your office receives the therapies, you will need to cross-reference the Therapies Įist email and match the vial number(s) to ensure that you are administering the correct therapy to the patient. If you ever have questions regarding therapy IDs, please notify the branch office immediately (info@rgcc-international-northamerica.com)
  • The email will include a tracking number (AWB Number) for the shipment.
    • You MUST track the shipments during transit from the lab to your office. Please note that tracking information will likely not populate until the Monday before your shipment However, you still want to track your therapies shipment periodically and notify the branch office in the event of any delays.
  • Attached to the email, you will find Integrity Control Please review the attachments and save the files. In the event the therapies arrive at your office and do not match the integrity control documents, or there is any other question as to viability of the therapy, please reach out to the branch office IMMEDIATEĮY.
  • Sample Therapies Shipment Email:

• “You Have New Results in The Portal” Email:
  • When test results are available in the Portal, you will receive an email from a “No Reply” email address to the primary email listed in your portal.
  • The email will include the patient’s name as well as a link to the Portal for convenience.
  • To access the results, you will login to the Network Doctor’s Portal, open the Patient Profile, and locate the Next to the Order, you will see an option to View Results.
    • In the event the results are not available for review, please notify the branch office for assistance.
  • aCCH RCCC Test Results:
    • These results are not posted within the Instead, they are emailed directly to the Network Doctor. Please note that this test takes approximately 3-4 weeks for processing.

Therapies Shipping

• All therapies will be shipped from the lab in Creece to offices in the US and Canada, using our private shipping network.
• Temperature Controlled Environment ensures the correct temperature throughout the shipping process
• Reliable Delivery Time:
  • Shipments to arrive in US offices by Tuesday
  • Shipments to arrive in Canadian offices by Wednesday
• How the System Works:
  • Therapies Įist Confirmation Emails will be sent the week before your scheduled shipment.
    • You MUST respond by the date and time indicated in the email to ensure the therapy will ship on If you do not respond, the therapy will be reset to ship the following dispatch.
  • Therapies will ship from the lab on Thursday.
  • Shipping Notification Emails with tracking number information will be sent on Thursday (or Ïriday) after the therapy has shipped.
  • Shipments will arrive in your office by noon on Tuesday (US) or Wednesday (Canada).
• Cellular Therapies should be administered ASAP - as close to delivery time as possible but no later than end of business on Thursday.
• Ǫ-REstrains are shelf stable and can be administered at your convenience within 6 months.

Shipping a Blood Specimen to the Lab

Upon Arrival of the Kit:

• Remove the icepacks from inside the kit and place in the freezer.
• ICE PACKS MUST BE ÏROZEN ÏOR AT ĮEAST 24 HOURS BEFORE SHIPPING.

How To Pack the Box for Shipping:

1. Open the box and remove the top foam piece.
2. Remove the gray molded foam from the white box.
3. Place the molded foam inside the Biohazard bag along with the absorbent sheet.
4. Place Biohazard bag with molded foam back inside the white box.
5. Place each 30 ml blood collection vial into the round slots in the molded foam.
   1. If sending “Additional Substances” for Onconomics Extracts or Onconomics Plus, place samples in the rectangular slot.
6. Seal the Biohazard bag making sure to remove any extra air.
7. Insert the 2 frozen icepacks on either side of the molded foam, outside of the Biohazard bag, in the spaces provided.
8. Close the white box.
9. Replace the top of the foam.
10. Ïold the paperwork in half and place it on top of the foam inner box.
11. Seal the box with packing tape.
    *Make sure that no tape is touching the UN3373 label on the box.
12. Place the prepaid shipping label with the barcode on the top of the box.
13. Place the adhesive ÏedEx pouch on the side of the box without the UN3373 label.
14. Ïold shipping documents and place inside the adhesive pouch.
15. Your kit is now ready for pickup/shipping.
    1. Call ÏedEx at (866) 393-4585 to schedule a pickup.

Please Note: The best days to ship blood samples to the lab are Monday, Tuesday, and Wednesday. This is to avoid the shipment getting stuck in customs over the weekend extending shipping times, which can affect the viability of the specimen when it arrives at the lab.

If ÏedEx does not service your area reliably, please notify our Customer Relations team and we will assist you in utilizing our DHĮ account for courier pickup.

Documentation Inside the Box:

• 1 copy of the Order Confirmation Form for each patient order.
• 1 copy of the Audit Form (nothing needs to be filled in on this form)
• 1 copy of the Material Data Invoice (fill in the highlighted sections)
• 1 copy of virus/Lyme test results if needed.
• Fold documentation in half and place on top of the insulating foam before sealing the box

Documentation Outside the Box:

• Place 1 pre-paid FedEx shipping label on the top of the box
• Attach the adhesive FedEx pouch to the long side of the box without the UN3373 label on it
• DO NOT cover any part of the UN3373 label
• Place the following documents in the adhesive pouch:
  • 2 remaining FedEx shipping labels. Keep the 3rd for your records and tracking.
  • 3 copies of the FedEx Commercial Invoice (fill in the highlighted sections)

To Schedule a Pickup: Call ÏedEx at (866) 393-4585

Resources: You can find copies of the Shipping Instruction Cuide and shipping documents on the Resource page of the portal.

Cancellations fi Refunds

Types of Cancellations fi Refunds:

• In-Portal Cancellations
  • Ïor orders that were recently placed – Click the “Cancel Order” button
  • Read the cancellation policy pop-up
  • Confirm the cancellation
  • The lab will be notified and a refund will be issued based on the cancellation , as outlined in the Cancellation Policy

● Manual Refunds

• When the “Cancel Order” button no longer appears in the portal
• When canceling part of an In-portal cancellation can only be used when the full order is being canceled
• When downgrading an order (ex. Oncotrace to Oncocount, or Onconomics Plus to Onconomics Extracts)
• No cells found – When one of the Onconomics panels is ordered but not cells are found, testing cannot proceed and will be downgraded to an Oncotrace. Please note: it will be the responsibility of the providers office to email info@rgcc-international-northamerica.com to request a refund of the price difference between the two Due to patient privacy we will not have access to the patients test results and have no way of knowing a refund needs to be issued unless we are notified via email.
• Full Refunds
  • A full refund is given when the order is placed but not sent to the lab
• Partial Refunds
  • When an order is placed and shipped
    • The cost of the kit and shipping is included in the price of the
    • If the order is canceled before arriving at the lab, a full refund will be issued less the kit fee to cover the hard costs of the kit and shipping charges

BioCentuar Refunds

Please submit all BioCentuar refund requests to Susan Bater at Susan.Bater@biocentuar.com

Cancellation Policy:

Cancellation of orders and refunds will be processed as follows:

• Cancellation Before Sample Is Shipped: Refund issued at 100%.
• Cancellation After Kit Has Been Drop-Shipped to Patient, Before Sample Is Shipped: 100 Euro kit fee will be deducted from the full price of the order or invoiced if order has not yet been
• Cancellation In Transit Before Arrival at the Įab: 100 Euro kit fee will be deducted from the full price of the Cancellation Ïee 100 Euro.
• Cancellation Upon Arrival and/or In Response to “Incoming Samples” Email: Refund issued at 50%. Cancellation fee 50%.
• Cancellation Between Confirmation of “Incoming Samples” Email and 24 Hours from Completion: Refund issued at 25%. Cancellation fee 75%
• Cancellation Within 24 Hours of Order Completion: No Cancellation fee 100%

Refunds issued take approximately 5-10 business days to appear in your bank or credit card account.

Setting Patient Expectations:

• Managing patient expectations is important so everyone is on the same page – this includes the patient, your office, and the RCCC lab and North America Branch Office staff.
• Test turn-around times and when to expect results:
  • RCCC requests two weeks from when the blood arrives at the lab for processing of all tests (and 3-4 weeks for ArrayCCH RCCC tests). Please note that processing times are approximate and not absolute.
• Shipping of therapies and timing of therapy administration:
  • Ǫ-REstrain have an 8 working day production time and are usually shipped 2-3 weeks from when the blood (and all required documentation) is received at the Please do not schedule therapy administration until you have received notification from the lab that the order has shipped.
  • Cellular therapies have a 15 working day production time and are usually shipped 3-4 weeks from when the blood and all other documentation is received at the Please do not schedule therapy administration until you have received notification from the lab that the order has shipped.

Office Best Practices:

• Track your shipments
  • This includes blood specimens going to the lab AND therapies shipments going to your office.
  • FedEx and DHĮ are typically very However, there are times when shipments are delayed or lost in transit. Tracking shipments going in both directions ensures that, in the event of any delay, we can get ahead of the issue before it becomes a bigger problem, ultimately avoiding any further delays in patient care.
  • If you notice that a blood specimen or therapy is delayed, please reach out to our Customer Relations team ASAP so we can assist in getting the shipment moved along or help you establish the best next steps to take.
  • RCCC suggests creating an Order Tracking Sheet, or other system of tracking orders, and including the following information:
    • Copy of Incoming Samples email
    • Approximate date of test results/therapy shipment
    • Copy of Therapies Įist email
    • Copy of Integrity Control documents
    • Copy of spreadsheet from Therapies Įist email, indicating Therapy IDs and patient information for each shipment
• Don’t schedule therapy administration until you know the therapies have shipped
• AĮWAYS send the Order Confirmation Document with your order - whether this is an order shipped to the lab, or an Add-On Your order cannot be processed without the Order Confirmation Document.
• Network Provider’s Responsibilities:
  • Confirming orders – responding to Incoming Samples and shipping emails
  • Confirming that Add-On Ǫ-REstrain orders have been received by the lab and are in process
  • Tracking shipments (blood specimens and therapies)
  • Tracking therapy ID information for when therapies arrive in office

Collaborating Offices

There are circumstances which require two RCCC Network doctors to collaborate on patient care. This may include a patient having their blood draw done at another office or having a therapy administered with another provider. In these instances, it is important for the primary doctor managing the patient’s care to place all orders. This will avoid confusion for office staff and the patient.

• If a collaborating office is performing a blood draw, the primary or ordering office will email a copy of the Order Confirmation form to the collaborating office so they can place it in the box along with the blood sample.
• If a collaborating office is administering a therapy, the primary or ordering office will notify the lab to ship the therapy directly to the collaborating It is the responsibility of the primary or ordering office to forward all notification emails containing information about the therapy’s shipment and expected arrival date to the collaborating office so they can schedule the administration properly.
  • If an Ǫ-REstrain is already at the primary office and needs to be transferred to a collaborating office, it must be transferred via courier directly from one office to another to retain the chain of custody and ensure proper handling of the Ǫ-REstrain. An Ǫ-REstrain vial should NEVER be given directly to a (see instructions below)
  • This option is not available for cellular  therapies.
• RCCC is happy to assist in locating a collaborating doctor, but all collaboration must be coordinated between the two offices directly.

Transferring/Shipping an Ǫ-REstrain to another Office

• When transferring an Ǫ-REstrain to another RCCC registered practice, we highly recommend having the patient complete a Release of Records (ROR) There is usually a line for "Other." This is where you would indicate the transfer of the Ǫ-REstrain. The Ǫ-REstrain should be sent to the other office via courier service (ÏedEx, UPS, etc.).
• NEVER send a therapy directly to the The ROR and courier ensure the chain of custody so all parties can be protected legally and remain confident the therapy was not contaminated in any way due to mishandling.

Cross-Branch Orders

• Definition: Orders placed by a physician located in a different country than the patient, and these countries are under the direction of different branch (ex. Physician is in the US or Canada. The patient is in the UK or Cermany)
• Each branch office functions as an independent entity within the RCCC Network and facilitates orders for physicians in countries within its Cross Branch orders are an exception to this rule.
• Regulations regarding shipping of biological substances varies from country to country. The branch office responsible for each specific country is versed in these regulations and can facilitate proper shipping and handling from the country where the blood sample is being shipped
• The order MUST be placed through the branch office where the patient resides or where the blood is being drawn and shipped The order is NOT placed through the branch where the physician is located.
• You will NOT place these orders in the North American To place a Cross Branch order for a patient in a different country, please follow the instructions below.

● How to Register for other Branch Offices

• Send an email explaining where your office is located and ask for the branch office that handles orders for the country where the patient is located.
• Send the email to office@rgcc-international.com, office@rgcc-genlab.com, and info@rgcc-international-northamerica.com. Please send this email to all 3 addresses.
• You will be given contact information for the branch office you will need to connect with to place the order.
• Since the North America branch portal is the only portal that contains the  in-portal payment system, you will need to be given login credentials for the portal used in the rest of the world. The order process within the portal is the same, but kit ordering, and payment are facilitated through the branch.
• Since each branch operates independently, you will follow the guidance they provide to complete your The North America branch will not be able to assist with placing or tracking these orders.

Pricing Policy

• Up-Charging for RCCC related tests and therapies is strictly prohibited.
  • All RCCC pricing for tests and therapies is published on the RCCC website and available to patients upon request.
  • The prices of tests and therapies are fixed, published, and should not be changed.
    • However, that does not prohibit you from charging fees for consultations, blood draws, administrative time, or any other services you may provide in order to administer the test and/or This is standard practice in any office. We do not expect you to provide all of these services without charge. Your time and expertise have value and we support you in billing for them. We simply ask you not to upcharge the price of the tests and therapies themselves.
• Here are a few models you can use:
  • A Įa Carte:
    • List the price of the test, separately from other service fees.
  • Bundled:
    • Present a single price for testing/therapy + additional in-office services necessary for the proper administration of the test and/or therapy.
    • Present the bundle as a “Package” (ex. Ǫ-REstrain Bundle or Ǫ-REstrain Package) to avoid the appearance of asking an inflated price that differs from the published price of the single test or therapy.
    • Make sure to list all items included in the bundled or package to demonstrate the value of the price being quoted.

In both instances, the price of RCCC tests and therapies remains fixed, while you bill for the additional value of the services you provide.

Pricing Policy – Kits/Supplies/Shipping Ïees

• Charging for RCCC related supplies and shipping is strictly prohibited.
  • The cost of all testing supplies and shipping fees are included in the price of the tests and therapies, therefore, these supplies are provided to your office at no charge.
  • These statements are published on the website and the patient has already paid for these items.

Payment Policy

This policy applies to all manual invoices issued for charges that are not able to be paid for with the in-portal payment system. (ex. Upgrades or additional substances)

• All manual invoices will be sent to your email It is your responsibility to forward the invoice to the patient if you wish for the patient to pay directly.
• All invoices are the responsibility of the ordering physician even if the invoice is to be paid by the patient.
• You are, as the registered physician, the RCCC customer, and therefore, responsible for all open or outstanding balances.
• If a patient does not pay the manual invoice, your office will be contacted to make sure the payment is made.
• If the payment remains unpaid beyond 60 days, the registered office will be placed on probation.
• If the payment remains unpaid beyond 90 days, your portal access will be locked, and you will not be able to place additional orders, until the account is brought current.

Probationary Action

RCCC is not like other labs. We require a level of commitment on behalf of the doctor, their staff, and their patient(s). We require certain standards to be consistently met to remain one of our active providers. All providers are given necessary training and ongoing support regarding our processes, tests, and therapies therefore excuses of ignorance are not acceptable.

Should our office receive a formal complaint from a patient or provider, it may be deemed necessary to put the offending office on probation. While this is never our hope, we understand that oversights and mistakes may happen and we view this as an opportunity for growth and an improved relationship between RCCC and the office.

As a reminder, RCCC’s requirements include but are not limited to the following:

• As the registered RCCC provider, you must act in the role of a patient care clinician.
• Someone in your office must be designated as the primary person in charge of ensuring the test requirements are This person must be willing to undergo training with us, this includes if you have a personnel change.
• Patient’s paperwork must be filled out properly in the Mistakes can cause the test sample to be rejected and a cancellation fee to be applied.
• Patients blood specimens must be drawn If you are not drawing at your clinic, it is still your responsibility to ensure that the drawing lab knows how to do it properly. We have written instructions available for reference in the Resources section of the Portal.
• Payment to RCCC for the appropriate test or therapy must be made prior to the blood specimen being sent to the lab for processing.
• We require the clinician to understand how to interpret RCCC test results and to be able to formulate a We offer providers complementary training with one of our doctors in the Clinical Support department. Complaints from patients that they were not explained the results or given a protocol based on their results is not acceptable and can lead to you losing the ability to order our tests and/or therapies.
• You must be certified to offer a specific RCCC Being a RCCC provider does not give you the ability to order therapies without the proper training.
• We require the providers offering RCCC therapies to fully understand and implement the guidelines This includes understanding the contraindications, the pre and post therapy guidelines, proper administration of the therapy, and appropriate follow up care (including any required questionnaires for research purposes). This also includes proper handling of all therapies, following the correct chain of custody when transferring a therapy to another office for administration, and NEVER sending a therapy directly to a patient.

When a provider’s office is placed on probation, they will receive a Probationary Memo outlining the details of the violation, as well as a plan of action to correct the violation. The office will be required to review and acknowledge the Probationary Memo by signing and returning it to our office. A first offense will result in a 90 day probation period, where the provider’s office will be under careful watch by the RCCC North America team. They will also be removed from our referral list. Once the 90 days have concluded, our team will re-evaluate the situation and carefully examine the behavior of the office over the course of the 90 days. At that time, a determination will be made as to whether or not the office can be removed from probation or if additional action is needed. Please reach out to Customer Relations for additional information on the probationary action policy.

Blood Draw Comprehensive Information Pre- and post-blood draw guidelines

The guidelines recommended below were developed over multiple years of research by RCCC. The main purpose of these recommendations is to allow the lab to provide reliable and accurate test results, without being affected by other parameters (eg. transportation).

For virus/Lyme (V. Antagonist) SOT:

The patient must be off AĮĮ antiviral/antibacterial/antiparasitic medications and therapies for 14 days prior to the blood draw. These include antibiotics, antiviral medications, and herbs, as well as IVs like Vitamin C or Ozone.

Note: Detox supplements, such as binders, glutathione, cytokine reducers, etc. will not interfere with the action of the SOT and can be used pre-SOT blood draw.

For cancer tests, cancer therapies, and Immune-frame:

The patient must be off AĮĮ cytotoxic and free radical producing therapies.

For Onco-D-clare test:

The patient must be off all immune suppressive therapies. This includes steroids, anti-rejection medications, phospholipid therapy, various types of Peptides, etc.

If drawing blood for cellular therapies, the patient must be off AĮĮ immune-suppressing therapies as well. See the list below for specific timelines.

Reason: The breakdown of the CTC caused by these therapies creates debris and clouds the field. Removing these therapies prior to the blood draw will allow time for the body to clear the debris, providing the best quality blood sample and ensuring better quality test results and therapy targets.

If drawing blood for cellular therapies, the patient should be off AĮĮ immune-suppressing therapies as well. See the list below for specific timelines.

Reason: The breakdown of the CTC caused by these therapies creates debris and clouds the field. Removing these therapies prior to the blood draw will allow time for the body to clear the debris, providing the best quality blood sample and ensuring better quality test results and therapy targets.

Recommended substances to be avoided pre-blood draw

*note that these are suggestions only. RCCC leaves discretion to the ordering practitioner and suggests that patients consult their practitioner prior to stopping or starting any substance.

• Blood Transfusions: at least 120 days
• CDK Inhibitors: for at least 14 days
• Chelation Therapy (IV): Avoid at least 14 days
• Chemotherapy (non-platinum derivative): at least 14 days
• Chemotherapy (platinum derivative): at least 21 days
• Cryoablation: at least 7 days
• Ïever: at least 14 days
• Camma Delta T Cell Therapy (CDTC): Patients are not eligible for therapies due to the potential interaction with RCCC therapies.
• Hormone suppression: at least 14 days (½ life x 7 is ideal formula for avoidance)
• Hyperbaric Therapy: at least 7 days
• Hyperthermia (generalized/systemic): no waiting
• Hyperthermia (local/concentrated/microwave ablation): at least 30 days due to increased cellular debris released into the bloodstream
• Immune Suppression Medication: at least 14 days
• Methylene Blue: at least 14 days
• Mistletoe: Avoid for at least 21 days (can beneficial after therapy administration)
• MOAB or SMW drugs: for at least 14 days
• Natural Substances (IV): cytotoxic substances like Vitamin C or Ozone at least 14
• Natural Substances (oral supplements): Class 1 or 3 cytotoxic substances (per patient’s Onconomics Plus results) at least 14 days.
• NK1 Inhibitors: for at least 14 days
• NSAIDS: Do not have to be discontinued
• Off Įabel Medications: Ivermectin-ÏenBen-Itraconazole: 14 days
• Off Įabel medication: Doxycycline: 7 days
• Off Įabel Medication: Metformin: 21 days
• PEMÏ Therapy: at least 7 days
• Plasmapheresis: Potential risk but not Use your own discretion.
• Radiation: at least 14 days
• Radioactive Seeds: Patients are not eligible for therapies due to the prolonged and undetermined time of the radiation exposure
• Scans with Contrast: at least 14 days
• Surgery (brain or extensive): minimum of 30 days based on time of Could be longer if slow recovery or if the person had some type of adverse reaction. Must be evaluated on a case-by-case basis.
• Surgery (simple/routine): at least 7-10 days

Post blood-draw:

• For cancer (Apoptosis): All therapies may be resumed the day after the blood draw.
• For virus/Įyme (V. antagonist): All therapies may be resumed the day after the blood draw.

Blood draw instructions

Blood draw instructions - Multi-fly needle method (30 ml glass vials)

1. Sterilize area.
2. Insert multi-fly needle and stabilize.
3. Ïit adapter to other/open end.
4. Remove inner circle of aluminum foil to expose rubber stopper on 30 ml vial in preparation for the blood DO NOT remove the entire foil cap.
5. Collect 2-3 ml of blood in a small vacutainer tube and discard it.
6. Collect 20-25 ml of blood in the 30 ml vial.
   1. Please note that the vial is filled under vacuum, and will fill automatically. Thus, you will collect the amount without adding any pressure.
7. Invert vial 3-4 times to mix Do not shake vigorously.
8. Complete label information, including patient name and date of birth. 
9. Place a 30 ml vial in a round slot in molded foam when ready for shipping.
10. If not shipping right away, store the vial in the refrigerator, no more than 24 hours before shipping. DO NOT freeze.

Blood draw instructions - Syringe method

1. Sterilize area.
2. Draw 2-3 ml of blood and discard.
3. Draw 20-25 ml of blood with a syringe.
4. Remove inner circle of aluminum foil to expose rubber stopper on 30 ml vial in preparation for the blood DO NOT remove the entire foil cap.
5. Place the needle of the syringe through the middle of the rubber stopper – blood will transfer automatically.
   1. You do not need to press the syringe, as this will cause issues with the pressure of the vial.
6. Remove the syringe and needle together.
7. Invert vial 3-4 times to mix Do not shake vigorously. 8. Complete label information.
8. Place a 30 ml vial in a round slot in molded foam when ready for shipping.
9. If not shipping right away, store the vial in the refrigerator, no more than 24 hours before shipping. DO NOT freeze.

Blood draw demonstration video: https://vimeo.com/787603633/cbd854d32c

Remote blood draw instructions

The remote blood draw option is available to patients who live at a distance from their RCCC practitioners. This can help avoid the time and expense of long-distance travel when needing an RCCC blood draw.

The RCCC practitioner will order a blood draw kit and have it drop-shipped to the patient’s address. The patient will need to find a blood draw service in their area to help. The kit is then shipped directly from the patient to the lab, after the blood draw is complete.

Simply follow the steps below:

1. Sending a kit to a patient (for North America providers only):
   1. The in-portal kits-vials order form allows for an alternate shipping address so you can drop-ship a kit directly to the patient (look for the purple bar at the bottom of the order form to edit the shipping address)
   2. Simply enter the exact quantity of isoboxes, vials, blood draw sets, labels, that the patient will need to complete the blood draw. Reference the Ǫuantities Cuide below to determine the number of vials to drop-ship, if needed.
   3. The warehouse will send the kit directly to your patient’s address, as specified in the order form.
   4. When all items are ordered, the kit will come complete with blood draw and shipping instructions. 
2. Placing the order:
   1. Place and pay for the order in the portal.
      Download the order confirmation form and email it to the patient so they can place it in the box along with the blood sample.
   2. Instruct the patient to write in the vial number(s) upon receipt of the kit.
3. Receiving the kit:
   1. As soon as the kit arrives, open the box, remove the ice packs, and place them in the The ice packs MUST be frozen for at least 24 hours before placing them back in the box for shipping.
   2. Confirm that all items needed to complete the blood draw are in the box.
      • Molded foam with slots for the vial
      • Biohazard bag (North America only)
      • 30ml glass collection vial(s)
      • Blood draw set (butterfly needle, adapter, and small blood draw vial with a purple top).
      • Blood draw instructions for the phlebotomist (North America only)
      • Shipping instructions (North America only)
      • Shipping documents (North America only)
        • Material data invoice (1 copy)
        • Audit form (1 copy)
        • Commercial invoice (3 copies)
          • Shipping labels (1 with a barcode, without barcode)
            • Order Confirmation Ïorm (emailed to you by your practitioner)
4. All contents, including the ice packs, will need to be taken to the blood draw appointment.
   The practitioner will not know the vial number(s) before the kit arrives at the patient’s address. Please make sure to write the vial numbers on the Order Confirmation form.
5. Scheduling a blood draw:
   1. Blood draws should be scheduled, and the kit should be shipped back to the lab, on Monday or Tuesday to ensure the sample will arrive at the lab in a timely manner. If shipped later in the week, the kit may not clear customs before the weekend, extending the shipping time.