The Immune Frame test by RGCC is a specialized diagnostic tool used to evaluate a patient’s immune system status and determine their eligibility for cellular therapies. It provides critical insights into the immune system's function and readiness, helping establish a baseline for treatment and monitoring therapeutic response over time. Here’s what it offers and how it works:

How the Immune Frame Test Works

1. Blood Sample Collection
   • A non-invasive blood draw provides the sample needed for immune system evaluation.
2. Comprehensive Immune Status Assessment
   • The test evaluates the patient’s immune function, focusing on the following key areas:
     • Cachexia (Wasting Syndrome): Identifies signs of significant weight and muscle loss that could impact treatment readiness.
     • Dendritic Cells (DCs): Measures the presence and stimulation of dendritic cells, critical for initiating immune responses.
     • Specific Humoral Immunity: Assesses antibody-mediated immunity.
     • Specific Cellular Immunity: Evaluates the activity of immune cells directly targeting pathogens or tumor cells.
     • Non-Specific Cellular Immunity: Measures generalized immune responses not specific to particular antigens.
     • Immunosuppressive Mechanisms: Detects factors that may be suppressing immune activity, which could affect therapy outcomes.
     • Activation of T and B Memory Cells: Analyzes the readiness of memory cells to provide long-term immunity and sustained immune responses.
3. Baseline Establishment and Monitoring
   • The test creates an initial baseline to guide cellular therapy decisions and track immune response over time.

Key Applications of the Immune Frame Test

1. Eligibility for RGCC Cellular Therapies
   • The Immune Frame test is a prerequisite for RGCC cellular therapies, ensuring that the patient’s immune system is suitable for advanced interventions such as dendritic cell therapies or personalized cancer vaccines.
2. Treatment Algorithm Guidance
   • Provides essential data to guide the treatment algorithm, optimizing the effectiveness of cellular therapies based on the patient’s immune status.
3. Therapeutic Monitoring
   • Tracks the immune system’s response to therapy over time, enabling adjustments to the care plan as needed to ensure the best outcomes.

Key Benefits of the Immune Frame Test

1. Precision in Therapy Selection:
   • Determines whether a patient’s immune system is ready for cellular therapies, helping to avoid ineffective or premature interventions.
2. Baseline and Ongoing Monitoring:
   • Establishes a starting point for immune function and tracks progress throughout treatment, ensuring therapies are working as intended.
3. Comprehensive Immune Insights:
   • Evaluates both specific and non-specific immune responses, including factors affecting long-term immunity and immunosuppression.
4. Enhanced Treatment Planning:
   • Identifies potential barriers to immune system effectiveness, allowing for interventions to optimize readiness and response to therapy.

The Immune Frame test is an essential component of precision cancer care, offering a detailed understanding of immune system function. By identifying eligibility for RGCC cellular therapies and guiding treatment decisions, it ensures that patients receive the most appropriate and effective care for their unique health needs. This test provides the foundation for successful therapeutic interventions and long-term immune health.